SH3RF2

Across TCGA cell cohorts, SH3RF2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3RF2-associated genes across cancer lineages are OR1L3, SCGB3A2, and ADAMTS18. Each is linked with SH3RF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3RF2-to-partner and partner-to-SH3RF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by SH3RF2-low versus SH3RF2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF2→partner) and Y-score (partner→SH3RF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L3 →	+0.028	+4.444	.005	.001	3	3
SKIN	SCGB3A2 →	+0.055	+3.217	<.001	.006	3	2
SKIN	ADAMTS18 →	+0.435	+3.443	.002	.009	3	1
SKIN	TPPP2 →	+0.048	+3.217	<.001	.006	3	1
SKIN	FAM71C →	+0.010	+3.832	.003	<.001	3	1
SKIN	CDR1 →	+0.185	+3.242	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

OR1L3 by SH3RF2 expression — OVARY

Explore this box plot interactively →