SH3RF1

Across TCGA pan-cancer cohorts, SH3RF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SH3RF1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SH3RF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3RF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where SH3RF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.002	42	view →
LSCC	DFS	Tertile	III,IV	0.408	1.000	.006	27	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	20	view →
CCRCC	OS	Quartile	III,IV	0.825	0.390	.023	10	view →
OV	DFS	Median	All	0.825	1.000	.027	4	view →
PDAC	DFS	Median	III,IV	0.514	0.231	.023	4	view →
GBM	OS	Median	All	0.678	0.848	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SH3RF1–UCEC (DFS)

Open the UCEC breakdown →