SH3RF1

Across TCGA patient cohorts, SH3RF1 mutation is significantly associated with the RNA expression of many other genes, with 2,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3RF1-associated genes across cancer lineages are CHCHD4, MRM3, and DEPDC1. Each is linked with SH3RF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3RF1-to-partner and partner-to-SH3RF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD4 grouped by SH3RF1-low versus SH3RF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF1→partner) and Y-score (partner→SH3RF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD4 →	+0.275	+1.454	.005	.003	3	3
UCEC	MRM3 →	+0.328	+2.592	.001	<.001	3	3
UCEC	DEPDC1 →	+0.469	+1.443	.008	.003	3	3
UCEC	RAD51 →	+0.742	+2.110	<.001	<.001	3	3
SKCM	PITHD1 →	+0.379	+3.217	.009	.009	3	3
UCEC	TIMM21 →	+0.452	+2.688	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,894 associations by consensus.

CHCHD4 by SH3RF1 expression — UCEC

Explore this box plot interactively →