SH3RF1

Across TCGA patient cohorts, SH3RF1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3RF1-associated genes across cancer lineages are NF-kB-p65_pS536, PI3K-p85, and eIF4E. Each is linked with SH3RF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3RF1-to-partner and partner-to-SH3RF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by SH3RF1-low versus SH3RF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF1→partner) and Y-score (partner→SH3RF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF-kB-p65_pS536 →	-0.463	-3.000	.013	.034	3	2
SKCM	PI3K-p85 →	-0.299	-2.459	.003	.020	3	2
UCEC	eIF4E →	+0.184	+3.598	.009	.001	3	2
UCEC	PCNA →	+0.192	+1.700	.007	.040	3	2
UCEC	ATM →	-0.574	-1.874	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.519	+1.434	.009	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

NF-kB-p65_pS536 by SH3RF1 expression — SKCM

Explore this box plot interactively →