SH3RF1

Across TCGA cell cohorts, SH3RF1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3RF1-associated genes across cancer lineages are FOXI2, PGLYRP4, and ZNF716. Each is linked with SH3RF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3RF1-to-partner and partner-to-SH3RF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXI2 grouped by SH3RF1-low versus SH3RF1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3RF1→partner) and Y-score (partner→SH3RF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FOXI2 →	+0.006	+4.930	<.001	.008	3	2
SOFT_TISSUE	PGLYRP4 →	+0.016	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	ZNF716 →	+0.462	+3.882	<.001	.003	3	1
LUNG_NSCLC_LUAD	DDX53 →	+0.945	+3.477	<.001	.009	3	1
LUNG_NSCLC_LUAD	ZNF479 →	+0.025	+3.481	.003	.004	3	1
LUNG_NSCLC_LUAD	PGA4 →	+0.038	+3.882	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FOXI2 by SH3RF1 expression — SOFT_TISSUE

Explore this box plot interactively →