SH3PXD2B

Across TCGA pan-cancer cohorts, SH3PXD2B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SH3PXD2B data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SH3PXD2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SH3PXD2B expression acts as an unfavorable survival marker.

PDAC, LUAD, and CCRCC are the cancer types where SH3PXD2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.418	0.639	.020	19	view →
LUAD	OS	Quartile	All	0.681	0.895	.004	16	view →
CCRCC	DFS	Median	All	0.704	1.000	.008	6	view →
GBM	DFS	Median	All	0.638	0.852	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SH3PXD2B–PDAC (OS)

Open the PDAC breakdown →