SH3KBP1

Across TCGA pan-cancer cohorts, SH3KBP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3KBP1 data layer compared with 24 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SH3KBP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SH3KBP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, STAD, and LUAD are the cancer types where SH3KBP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
LUAD	OS	Median	II,III,IV	0.203	0.681	.003	6	view →
LUSC	OS	Median	II,III,IV	0.173	0.677	.029	3	view →
UCEC	OS	Median	II,III,IV	0.856	0.457	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3KBP1–READ (OS)

Open the READ breakdown →