SH3KBP1

Across TCGA patient cohorts, SH3KBP1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,996 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3KBP1-associated genes across cancer lineages are TMEM156, TRBV12-4, and GRAP2. Each is linked with SH3KBP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SH3KBP1-to-partner and partner-to-SH3KBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3KBP1 versus TMEM156 in LSCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3KBP1→partner) and Y-score (partner→SH3KBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM156 →	+1.050	+0.574	<.001	<.001	3	9
UCEC	TRBV12-4 →	+1.107	+0.348	<.001	.001	3	9
BRCA	GRAP2 →	+0.802	+0.398	<.001	<.001	3	8
BRCA	IL2RB →	+1.323	+0.420	<.001	<.001	3	8
BRCA	CORO1A →	+1.399	+0.471	<.001	<.001	3	8
BRCA	MAP4K1 →	+1.159	+0.434	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,996 associations by consensus.

SH3KBP1 vs TMEM156 — LSCC

Explore this scatter interactively →