SH3KBP1

Across TCGA patient cohorts, SH3KBP1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3KBP1-associated genes across cancer lineages are Notch1, Rictor_pT1135, and TIGAR. Each is linked with SH3KBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3KBP1-to-partner and partner-to-SH3KBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SH3KBP1-low versus SH3KBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3KBP1→partner) and Y-score (partner→SH3KBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.126	+2.013	.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.068	-1.392	.014	.017	3	2
UCEC	TIGAR →	+0.120	+1.126	.003	.010	3	2
UCEC	ASNS →	+0.359	+1.473	<.001	.005	3	2
UCEC	ATM →	-0.452	-2.124	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.621	+1.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by SH3KBP1 expression — UCEC

Explore this box plot interactively →