SH3KBP1

Across TCGA cell cohorts, SH3KBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,848 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3KBP1-associated GO terms across cancer lineages are Actin filament organization, Urokinase plasminogen activator signaling pathway, and Positive regulation of cell-substrate junction organization. Each is linked with SH3KBP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SH3KBP1-to-partner and partner-to-SH3KBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament organization grouped by SH3KBP1-low versus SH3KBP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3KBP1→partner) and Y-score (partner→SH3KBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament organization →	+0.106	+1.174	<.001	<.001	3	13
BREAST	Urokinase plasminogen activator signaling pathway →	+1.148	+1.774	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.173	+3.016	<.001	<.001	3	12
BONE	Regulation of protein maturation →	+0.219	+1.514	<.001	<.001	3	12
BONE	Regulation of proteolysis →	+0.126	+1.412	<.001	<.001	3	12
BONE	Regulation of protein processing →	+0.195	+1.544	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,848 associations by consensus.

Actin filament organization by SH3KBP1 expression — BONE

Explore this box plot interactively →