SH3KBP1

Across TCGA cell cohorts, SH3KBP1 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SH3KBP1-associated genes across cancer lineages are PRAMEF12, FSHB, and ZPBP2. Each is linked with SH3KBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3KBP1-to-partner and partner-to-SH3KBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by SH3KBP1-low versus SH3KBP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3KBP1→partner) and Y-score (partner→SH3KBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF12 →	+0.519	+4.315	<.001	.006	3	1
CNS	FSHB →	+0.024	+4.321	<.001	.009	3	1
CNS	ZPBP2 →	+0.066	+4.754	<.001	.005	3	1
CNS	LEUTX →	+0.166	+4.321	<.001	.009	3	1
CNS	CELA3B →	+0.137	+4.754	<.001	.005	3	1
CNS	PRAMEF5 →	+0.344	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PRAMEF12 by SH3KBP1 expression — CNS

Explore this box plot interactively →