SH3GLB2

Across TCGA pan-cancer cohorts, SH3GLB2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3GLB2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SH3GLB2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SH3GLB2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where SH3GLB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.857	0.609	.010	28	view →
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	26	view →
LSCC	OS	Quartile	All	0.637	0.905	.014	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	OS	Quartile	All	0.301	0.679	.008	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3GLB2–HNSC (OS)

Open the HNSC breakdown →