SH3GLB2

Across TCGA patient cohorts, SH3GLB2 mutation is significantly associated with the RNA expression of many other genes, with 1,022 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GLB2-associated genes across cancer lineages are MIR668, KRTAP20-3, and MIR3689D2. Each is linked with SH3GLB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3GLB2-to-partner and partner-to-SH3GLB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR668 grouped by SH3GLB2-low versus SH3GLB2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB2→partner) and Y-score (partner→SH3GLB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR668 →	+0.768	+7.954	<.001	.008	3	3
UCEC	KRTAP20-3 →	+0.118	+5.060	<.001	<.001	3	2
HNSC	MIR3689D2 →	+0.608	+7.954	<.001	.008	3	2
SKCM	TUBB8P10 →	+0.048	+4.913	<.001	.002	3	2
SKCM	RNU7-167P →	+0.802	+4.970	<.001	.005	3	2
LUAD	RNA5SP412 →	+0.168	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,022 associations by consensus.

MIR668 by SH3GLB2 expression — HNSC

Explore this box plot interactively →