SH3GLB2

Across TCGA patient cohorts, SH3GLB2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GLB2-associated genes across cancer lineages are p62 Lck ligand, PDK1_pS241, and PTEN. Each is linked with SH3GLB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GLB2-to-partner and partner-to-SH3GLB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SH3GLB2-low versus SH3GLB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB2→partner) and Y-score (partner→SH3GLB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.367	+3.459	.024	.005	3	1
UCEC	PDK1_pS241 →	+0.291	+3.196	<.001	.009	3	1
UCEC	PTEN →	-0.406	-2.321	.042	.035	3	1
UCEC	YB-1 →	-0.194	-2.295	.015	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.194	+3.019	<.001	.019	3	1
UCEC	Cyclin-B1 →	+0.599	+3.459	.033	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by SH3GLB2 expression — UCEC

Explore this box plot interactively →