SH3GLB2

Across TCGA cell cohorts, SH3GLB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,380 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3GLB2-associated GO terms across cancer lineages are Sperm motility, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with SH3GLB2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SH3GLB2-to-partner and partner-to-SH3GLB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sperm motility grouped by SH3GLB2-low versus SH3GLB2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB2→partner) and Y-score (partner→SH3GLB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.167	-1.283	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.156	-1.328	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.156	-1.328	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.160	-1.210	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Golgi to endosome transport →	+0.110	+1.174	<.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.167	-1.283	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,380 associations by consensus.

Sperm motility by SH3GLB2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →