SH3GLB2

Across TCGA cell cohorts, SH3GLB2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3GLB2-associated genes across cancer lineages are TEX101, TKTL2, and CYYR1. Each is linked with SH3GLB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GLB2-to-partner and partner-to-SH3GLB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX101 grouped by SH3GLB2-low versus SH3GLB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GLB2→partner) and Y-score (partner→SH3GLB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX101 →	+0.157	+3.502	<.001	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.044	+3.509	<.001	.001	3	1
LARGE_INTESTINE	CYYR1 →	+0.019	+3.256	.002	.005	3	1
LARGE_INTESTINE	SLC6A19 →	+1.577	+3.719	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TEX101 by SH3GLB2 expression — LARGE_INTESTINE

Explore this box plot interactively →