SH3GL3

Across TCGA pan-cancer cohorts, SH3GL3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SH3GL3 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SH3GL3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH3GL3 expression acts as an unfavorable survival marker.

LUAD, GBM, and HNSC are the cancer types where SH3GL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.166	0.813	<.001	38	view →
GBM	DFS	Tertile	All	0.326	0.537	.039	3	view →
HNSC	DFS	Quartile	All	0.566	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SH3GL3–LUAD (DFS)

Open the LUAD breakdown →