SH3GL3

Across TCGA patient cohorts, SH3GL3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,822 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH3GL3-associated genes across cancer lineages are ABHD6, DOCK9-AS1, and DOCK9. Each is linked with SH3GL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3GL3 versus ABHD6 in HNSC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABHD6 →	+0.904	+0.703	<.001	<.001	3	2
HNSC	DOCK9-AS1 →	+0.759	+0.718	.001	.003	3	2
GBM	DOCK9 →	+0.663	+0.808	<.001	<.001	3	2
LUAD	NIBAN2 →	-0.475	-0.750	.007	.008	3	2
LUAD	GNG5 →	-0.554	-0.772	.002	.003	3	2
LUAD	RNU6-1098P →	-1.050	-0.660	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,822 associations by consensus.

SH3GL3 vs ABHD6 — HNSC

Explore this scatter interactively →