SH3GL3

Across TCGA patient cohorts, SH3GL3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GL3-associated genes across cancer lineages are Cyclin-B1, eEF2, and ERK2. Each is linked with SH3GL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SH3GL3-low versus SH3GL3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.531	+3.012	.006	.018	3	3
UCEC	eEF2 →	+0.235	+2.000	.042	.029	3	2
UCEC	ERK2 →	+0.131	+2.000	.036	.029	3	2
UCEC	MSH2 →	-0.202	-1.739	.006	.012	3	2
UCEC	p27_pT198 →	+0.073	+1.222	.034	.035	3	2
UCEC	PDCD4 →	-0.398	-1.222	.009	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by SH3GL3 expression — SKCM

Explore this box plot interactively →