SH3GL3

Across TCGA cell cohorts, SH3GL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,955 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3GL3-associated GO terms across cancer lineages are Negative regulation of clathrin-dependent endocytosis, Potassium ion transport, and Potassium ion transmembrane transport. Each is linked with SH3GL3 in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of clathrin-dependent endocytosis grouped by SH3GL3-low versus SH3GL3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of clathrin-dependent endocytosis →	-0.215	-0.524	.006	<.001	3	11
OVARY	Potassium ion transport →	-0.073	-1.136	<.001	.002	3	9
OVARY	Potassium ion transmembrane transport →	-0.067	-0.972	<.001	.008	3	9
OESOPHAGUS	Inorganic cation import across plasma membrane →	-0.102	-1.434	<.001	<.001	3	9
OESOPHAGUS	Inorganic ion import across plasma membrane →	-0.102	-1.434	<.001	<.001	3	9
OESOPHAGUS	Regulation of myoblast fusion →	+0.136	+1.436	.002	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

Negative regulation of clathrin-dependent endocytosis by SH3GL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →