SH3GL3

Across TCGA cell cohorts, SH3GL3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SH3GL3-associated genes across cancer lineages are TOPAZ1, OR5M8, and ECRG4. Each is linked with SH3GL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by SH3GL3-low versus SH3GL3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TOPAZ1 →	+0.006	+5.321	<.001	.005	3	1
CNS	OR5M8 →	+0.022	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	ECRG4 →	+0.068	+3.866	<.001	.006	3	1
LUNG_NSCLC_LUAD	C9orf92 →	+0.133	+4.628	.002	.001	3	1
LUNG_NSCLC_LUAD	USP17L11 →	+0.066	+3.734	<.001	.006	3	1
LARGE_INTESTINE	SCN11A →	+0.132	+3.772	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TOPAZ1 by SH3GL3 expression — CNS

Explore this box plot interactively →