SH3GL3

Across TCGA cell cohorts, SH3GL3 mutation is significantly associated with the mutation status of many other genes, with 3,878 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3GL3-associated genes across cancer lineages are PCOLCE2, PPP1R10, and HOXA3. Each is linked with SH3GL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3GL3-to-partner and partner-to-SH3GL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCOLCE2 grouped by SH3GL3-low versus SH3GL3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL3→partner) and Y-score (partner→SH3GL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PCOLCE2 →	+6.014	+6.014	.001	.001	1	3
CNS	PPP1R10 →	+4.459	+5.277	.005	.005	1	3
CNS	HOXA3 →	+4.459	+5.277	.005	.005	1	3
CNS	SLC26A8 →	+4.459	+5.277	.005	.005	1	3
CNS	DNAJC16 →	+5.044	+5.614	.003	.003	1	3
CNS	RLF →	+6.044	+6.044	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,878 associations by consensus.

PCOLCE2 by SH3GL3 expression — BLOOD_Lymphoma

Explore this box plot interactively →