SH3GL2

Across TCGA pan-cancer cohorts, SH3GL2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SH3GL2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SH3GL2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SH3GL2 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where SH3GL2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3GL2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−1.877	<.001	12	view →
LUAD	Female	All	−1.472	<.001	9	view →
LSCC	Female	All	−1.510	<.001	8	view →
PDAC	All	II,III,IV	−0.747	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SH3GL2–CCRCC

Open the CCRCC breakdown →