SH3GL2

Across TCGA patient cohorts, SH3GL2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GL2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Notch1, and PREX1. Each is linked with SH3GL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3GL2-to-partner and partner-to-SH3GL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by SH3GL2-low versus SH3GL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL2→partner) and Y-score (partner→SH3GL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.503	+2.321	.016	.006	3	3
UCEC	Notch1 →	+0.176	+3.335	.002	.005	3	2
UCEC	PREX1 →	-0.254	-2.321	.024	.034	3	2
UCEC	S6_pS240_S244 →	+0.379	+2.321	.023	.034	3	2
UCEC	STAT3_pY705 →	-0.527	-2.700	<.001	.005	3	2
UCEC	Caspase-8 →	-0.310	-3.780	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Acetyl-a-Tubulin-Lys40 by SH3GL2 expression — UCEC

Explore this box plot interactively →