SH3GL2

Across TCGA cell cohorts, SH3GL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,785 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SH3GL2-associated GO terms across cancer lineages are Negative regulation of blood-brain barrier permeability, Epigenetic regulation of gene expression, and Cellular response to brain-derived neurotrophic factor stimulus. Each is linked with SH3GL2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SH3GL2-to-partner and partner-to-SH3GL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of blood-brain barrier permeability grouped by SH3GL2-low versus SH3GL2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL2→partner) and Y-score (partner→SH3GL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of blood-brain barrier permeability →	-0.413	-0.958	.004	<.001	3	13
CNS	Epigenetic regulation of gene expression →	+0.037	+0.926	.002	.008	3	9
OVARY	Cellular response to brain-derived neurotrophic factor stimulus →	-0.123	-1.166	.002	.001	3	8
OESOPHAGUS	mRNA 3'-end processing →	+0.094	+0.730	<.001	.007	3	8
OESOPHAGUS	Regulation of DNA repair →	+0.041	+0.675	.003	.001	3	7
OESOPHAGUS	Regulation of monoatomic cation transmembrane transport →	-0.054	-0.715	.001	.009	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,785 associations by consensus.

Negative regulation of blood-brain barrier permeability by SH3GL2 expression — SKIN

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