SH3GL1

Across TCGA patient cohorts, SH3GL1 RNA expression is significantly associated with the mutation status of many other genes, with 12,868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GL1-associated genes across cancer lineages are TP53, SYNE1, and ZFHX4. Each is linked with SH3GL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SH3GL1-to-partner and partner-to-SH3GL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by SH3GL1-low versus SH3GL1-high in PAAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL1→partner) and Y-score (partner→SH3GL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	TP53 →	+1.839	+0.269	.008	.002	3	5
LUAD	SYNE1 →	+1.520	+0.252	.002	.002	3	4
UCEC	ZFHX4 →	+1.022	+0.320	<.001	<.001	3	4
GBM	AHNAK2 →	+2.545	+0.335	.006	.008	3	4
STAD	NRXN3 →	+1.873	+0.309	.004	.007	3	4
BLCA	DNAH7 →	+2.021	+0.300	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,868 associations by consensus.

TP53 by SH3GL1 expression — PAAD

Explore this box plot interactively →