SH3GL1

Across TCGA patient cohorts, SH3GL1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3GL1-associated genes across cancer lineages are IGFBP2, JNK2, and Ku80. Each is linked with SH3GL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GL1-to-partner and partner-to-SH3GL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SH3GL1-low versus SH3GL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL1→partner) and Y-score (partner→SH3GL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.784	-2.222	.004	.011	3	1
UCEC	JNK2 →	+0.355	+2.469	<.001	.010	3	1
UCEC	Ku80 →	+0.225	+2.235	.025	.006	3	1
UCEC	NF2 →	+0.276	+1.700	.002	.044	3	1
UCEC	PDK1_pS241 →	+0.200	+3.026	.005	.018	3	1
UCEC	AMPK_pT172 →	+0.402	+2.920	.021	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IGFBP2 by SH3GL1 expression — UCEC

Explore this box plot interactively →