SH3GL1

Across TCGA cell cohorts, SH3GL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,376 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SH3GL1-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Vesicle uncoating. Each is linked with SH3GL1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SH3GL1-to-partner and partner-to-SH3GL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by SH3GL1-low versus SH3GL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL1→partner) and Y-score (partner→SH3GL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.153	+0.727	<.001	.002	3	17
CNS	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.128	+0.833	<.001	<.001	3	15
OVARY	Vesicle uncoating →	+0.139	+0.767	<.001	<.001	3	14
BREAST	Response to oscillatory fluid shear stress →	+0.162	+0.880	<.001	<.001	3	13
BREAST	Cellular response to oscillatory fluid shear stress →	+0.162	+0.880	<.001	<.001	3	13
BREAST	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.162	+0.880	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,376 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by SH3GL1 expression — LUNG_SCLC

Explore this box plot interactively →