SH3GL1

Across TCGA cell cohorts, SH3GL1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3GL1-associated genes across cancer lineages are ZP2, MYBPC3, and CFC1B. Each is linked with SH3GL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3GL1-to-partner and partner-to-SH3GL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZP2 grouped by SH3GL1-low versus SH3GL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3GL1→partner) and Y-score (partner→SH3GL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZP2 →	+0.062	+4.095	<.001	.009	3	1
SKIN	MYBPC3 →	+0.010	+4.273	.001	.006	3	1
SKIN	CFC1B →	+0.052	+5.022	<.001	.002	3	1
SKIN	OR13C3 →	+0.022	+5.022	<.001	.002	3	1
SKIN	ZNF99 →	+0.065	+4.273	<.001	.006	3	1
BLOOD_Lymphoma	PTH →	+0.017	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ZP2 by SH3GL1 expression — SKIN

Explore this box plot interactively →