Across TCGA patient cohorts, SH3D21 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,519 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SH3D21-associated proteins across cancer lineages are ENO2, AK4, and SLC2A1. Each is linked with SH3D21 in more than 4 cancer types. Because this analysis shows association rather than direction, both SH3D21-to-partner and partner-to-SH3D21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D21→partner) and Y-score (partner→SH3D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ENO2 →	+0.685	+0.870	.001	<.001	3	5
COAD	AK4 →	+0.625	+0.850	<.001	.001	3	5
COAD	SLC2A1 →	+0.751	+0.897	<.001	<.001	3	5
GBM	PLOD3 →	+0.526	+0.598	<.001	<.001	3	5
CCRCC	PTK7 →	+0.433	+0.540	.003	<.001	3	4
OV	DYNLL2 →	-0.341	-0.649	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,519 associations by consensus.

Exploration

SH3D21 survival (RNA) · tumor vs normal (RNA) · all SH3D21 data types