Across TCGA patient cohorts, SH3D21 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3D21-associated genes across cancer lineages are ERK2, ACC1, and Bak. Each is linked with SH3D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3D21-to-partner and partner-to-SH3D21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D21→partner) and Y-score (partner→SH3D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.205	+3.321	.018	.010	3	1
UCEC	ACC1 →	+0.374	+2.820	.022	.035	3	1
UCEC	Bak →	+0.263	+2.459	.020	.019	3	1
UCEC	Chk2_pT68 →	-0.183	-3.312	.028	.010	3	1
UCEC	14-3-3_beta →	-0.107	-2.301	.018	.034	2	1
UCEC	JNK2 →	+0.289	+3.331	.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SH3D21 survival (RNA) · tumor vs normal (RNA) · all SH3D21 data types