Across TCGA cell cohorts, SH3D21 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,926 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3D21-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Negative regulation of cytoplasmic pattern recognition receptor signaling pathway. Each is linked with SH3D21 in more than 9 cancer types. Because this analysis shows association rather than direction, both SH3D21-to-partner and partner-to-SH3D21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D21→partner) and Y-score (partner→SH3D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.102	+1.438	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription initiation by RNA polymerase II →	+0.102	+1.438	<.001	.001	3	10
KIDNEY	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.068	+1.467	.003	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.109	-1.090	.001	.001	3	10
LARGE_INTESTINE	Pre-mRNA catabolic process →	+0.161	+1.257	<.001	.006	3	10
URINARY_TRACT	Positive regulation of autophagy of mitochondrion →	+0.110	+1.239	<.001	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,926 associations by consensus.

Exploration

SH3D21 survival (RNA) · tumor vs normal (RNA) · all SH3D21 data types