Across TCGA cell cohorts, SH3D21 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3D21-associated genes across cancer lineages are TGM6, CST2, and OR10T2. Each is linked with SH3D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3D21-to-partner and partner-to-SH3D21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3D21→partner) and Y-score (partner→SH3D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CST2 →	+0.374	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10T2 →	+0.733	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.342	+4.551	<.001	.004	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LARGE_INTESTINE	GGA1 →	+0.549	+2.265	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

Exploration

SH3D21 survival (RNA) · tumor vs normal (RNA) · all SH3D21 data types