SH3BP5L

Across TCGA pan-cancer cohorts, SH3BP5L mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SH3BP5L data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SH3BP5L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SH3BP5L expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where SH3BP5L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.492	1.000	.007	18	view →
LUAD	DFS	Tertile	All	0.567	1.000	.001	18	view →
PDAC	DFS	Tertile	II,III,IV	0.236	0.554	.002	18	view →
HNSC	DFS	Quartile	All	0.851	0.529	.005	15	view →
GBM	OS	Median	All	0.728	0.896	.011	3	view →
CCRCC	OS	Tertile	All	0.778	0.926	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SH3BP5L–LSCC (OS)

Open the LSCC breakdown →