SH3BP5L

Across TCGA patient cohorts, SH3BP5L protein abundance is significantly associated with the RNA expression of many other genes, with 9,199 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SH3BP5L-associated genes across cancer lineages are SH3BP5, TOR1AIP2, and TRGC2. Each is linked with SH3BP5L in more than 4 cancer types. Because this analysis shows association rather than direction, both SH3BP5L-to-partner and partner-to-SH3BP5L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3BP5L versus SH3BP5 in GBM, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5L→partner) and Y-score (partner→SH3BP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SH3BP5 →	-0.670	-0.251	<.001	<.001	3	5
UCEC	TOR1AIP2 →	+0.455	+0.264	.002	<.001	3	4
HNSC	TRGC2 →	-0.919	-0.241	<.001	<.001	3	4
OV	ZNF496 →	+0.700	+0.390	.005	.001	3	3
OV	ZNF692 →	+0.668	+0.286	<.001	.004	2	4
HNSC	PIP5K1B →	-0.915	-0.387	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,199 associations by consensus.

SH3BP5L vs SH3BP5 — GBM

Explore this scatter interactively →