SH3BP5L

Across TCGA patient cohorts, SH3BP5L mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP5L-associated genes across cancer lineages are MSH2, ERK2, and INPP4B. Each is linked with SH3BP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP5L-to-partner and partner-to-SH3BP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by SH3BP5L-low versus SH3BP5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5L→partner) and Y-score (partner→SH3BP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.301	-1.807	.001	.027	3	2
UCEC	ERK2 →	+0.223	+3.169	.005	.018	3	1
UCEC	INPP4B →	-0.317	-3.459	.017	.005	3	1
UCEC	MEK1 →	+0.387	+2.321	.010	.006	3	1
UCEC	MSH6 →	-0.440	-3.321	.001	.009	3	1
UCEC	p27_pT198 →	+0.109	+3.000	.013	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MSH2 by SH3BP5L expression — UCEC

Explore this box plot interactively →