SH3BP5L

Across TCGA cell cohorts, SH3BP5L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,979 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SH3BP5L-associated GO terms across cancer lineages are Regulation of protein sumoylation, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration, and Positive regulation of protein sumoylation. Each is linked with SH3BP5L in more than 15 cancer types. Because this analysis shows association rather than direction, both SH3BP5L-to-partner and partner-to-SH3BP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein sumoylation grouped by SH3BP5L-low versus SH3BP5L-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5L→partner) and Y-score (partner→SH3BP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of protein sumoylation →	+0.134	+0.959	<.001	<.001	3	15
STOMACH	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.184	+0.870	<.001	<.001	2	16
LARGE_INTESTINE	Positive regulation of protein sumoylation →	+0.138	+0.980	<.001	<.001	3	14
CNS	Cytosolic transport →	+0.061	+0.831	<.001	<.001	3	14
STOMACH	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.134	+0.885	<.001	<.001	3	14
BONE	Subtelomeric heterochromatin formation →	+0.130	+0.766	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,979 associations by consensus.

Regulation of protein sumoylation by SH3BP5L expression — LARGE_INTESTINE

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