SH3BP5L

Across TCGA cell cohorts, SH3BP5L mutation is significantly associated with the RNA expression of many other genes, with 796 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH3BP5L-associated genes across cancer lineages are C12orf40, ASB17, and C1orf146. Each is linked with SH3BP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP5L-to-partner and partner-to-SH3BP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by SH3BP5L-low versus SH3BP5L-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5L→partner) and Y-score (partner→SH3BP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.545	+3.237	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.714	+3.619	<.001	<.001	3	1
LARGE_INTESTINE	TOMM22 →	+0.496	+3.321	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 796 associations by consensus.

C12orf40 by SH3BP5L expression — OVARY

Explore this box plot interactively →