SH3BP5

Across TCGA pan-cancer cohorts, SH3BP5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH3BP5 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SH3BP5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3BP5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where SH3BP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.943	0.753	.011	8	view →
CCRCC	DFS	Median	All	0.616	0.841	.004	4	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	4	view →
HNSC	DFS	Median	All	1.000	0.912	.042	3	view →
LSCC	DFS	Tertile	III,IV	1.000	0.827	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH3BP5–UCEC (DFS)

Open the UCEC breakdown →