SH3BP5

Across TCGA patient cohorts, SH3BP5 mutation is significantly associated with the RNA expression of many other genes, with 2,252 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP5-associated genes across cancer lineages are CDPF1, RNU6-927P, and PGAP2. Each is linked with SH3BP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3BP5-to-partner and partner-to-SH3BP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDPF1 grouped by SH3BP5-low versus SH3BP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5→partner) and Y-score (partner→SH3BP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDPF1 →	+0.338	+2.542	.001	<.001	3	3
UCEC	RNU6-927P →	+0.153	+2.126	.003	.003	3	3
UCEC	PGAP2 →	+0.324	+2.443	.004	<.001	3	2
UCEC	AP1S3 →	+0.701	+1.890	<.001	<.001	3	2
UCEC	C12orf43 →	+0.227	+2.447	.005	.001	3	2
UCEC	SSU72 →	+0.276	+2.440	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,252 associations by consensus.

CDPF1 by SH3BP5 expression — UCEC

Explore this box plot interactively →