SH3BP5

Across TCGA patient cohorts, SH3BP5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP5-associated genes across cancer lineages are MEK1, ATM, and Caspase-8. Each is linked with SH3BP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP5-to-partner and partner-to-SH3BP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SH3BP5-low versus SH3BP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5→partner) and Y-score (partner→SH3BP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.357	+1.874	.003	.002	3	2
UCEC	ATM →	-0.432	-1.584	.004	.009	3	2
UCEC	Caspase-8 →	-0.187	-1.584	.026	.009	3	2
UCEC	EGFR_pY1068 →	-0.277	-2.201	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.102	-1.906	.010	.015	3	1
UCEC	GATA6 →	-0.121	-2.307	.024	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by SH3BP5 expression — UCEC

Explore this box plot interactively →