SH3BP5

Across TCGA cell cohorts, SH3BP5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP5-associated genes across cancer lineages are PCDH11X, OR9G1, and KRTAP21-2. Each is linked with SH3BP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP5-to-partner and partner-to-SH3BP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11X grouped by SH3BP5-low versus SH3BP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP5→partner) and Y-score (partner→SH3BP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCDH11X →	+0.063	+3.029	.007	.003	3	1
BLOOD_Leukemia	OR9G1 →	+0.268	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IQCF5 →	+0.116	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PCDH11X by SH3BP5 expression — LARGE_INTESTINE

Explore this box plot interactively →