SH3BP4

Across TCGA pan-cancer cohorts, SH3BP4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SH3BP4 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SH3BP4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3BP4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where SH3BP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.859	0.569	.015	15	view →
HNSC	DFS	Tertile	IV	0.883	1.000	.026	9	view →
UCEC	DFS	Median	II,III,IV	0.870	0.531	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SH3BP4–CCRCC (DFS)

Open the CCRCC breakdown →