SH3BP4

Across TCGA patient cohorts, SH3BP4 protein abundance is significantly associated with the RNA expression of many other genes, with 16,200 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH3BP4-associated genes across cancer lineages are CRISPLD1, ZNF219, and SEPTIN2. Each is linked with SH3BP4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SH3BP4-to-partner and partner-to-SH3BP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3BP4 versus CRISPLD1 in OV, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP4→partner) and Y-score (partner→SH3BP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRISPLD1 →	+0.962	+0.342	.006	.002	3	6
OV	ZNF219 →	+0.946	+0.369	<.001	<.001	3	6
OV	SEPTIN2 →	+0.432	+0.308	<.001	.002	3	6
LUAD	SMOX →	+0.792	+0.264	.003	<.001	3	6
UCEC	ARHGAP9 →	-0.622	-0.265	.002	.004	3	6
UCEC	GPR65 →	-0.844	-0.407	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,200 associations by consensus.

SH3BP4 vs CRISPLD1 — OV

Explore this scatter interactively →