SH3BP4

Across TCGA patient cohorts, SH3BP4 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP4-associated genes across cancer lineages are GAPDH, eIF4E, and Rab25. Each is linked with SH3BP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3BP4-to-partner and partner-to-SH3BP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SH3BP4-low versus SH3BP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP4→partner) and Y-score (partner→SH3BP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.698	+2.128	<.001	.009	3	3
COAD	eIF4E →	+0.195	+1.832	.003	.015	3	3
COAD	Rab25 →	-0.219	-1.798	.025	.026	3	3
SKCM	Cyclin-B1 →	+0.532	+2.182	.006	.033	3	3
STAD	TIGAR →	+0.541	+3.000	.010	.034	3	2
COAD	eEF2 →	+0.390	+2.330	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

GAPDH by SH3BP4 expression — COAD

Explore this box plot interactively →