SH3BP4

Across TCGA cell cohorts, SH3BP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,878 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH3BP4-associated GO terms across cancer lineages are Actin filament organization, Regulation of actin filament organization, and Regulation of cellular response to transforming growth factor beta stimulus. Each is linked with SH3BP4 in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3BP4-to-partner and partner-to-SH3BP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament organization grouped by SH3BP4-low versus SH3BP4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP4→partner) and Y-score (partner→SH3BP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament organization →	+0.164	+2.257	<.001	<.001	3	11
BONE	Regulation of actin filament organization →	+0.061	+1.760	<.001	<.001	3	11
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.075	+2.712	<.001	<.001	3	11
LIVER	Regulation of cell projection assembly →	+0.046	+1.361	<.001	.001	3	10
SOFT_TISSUE	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.065	+2.902	<.001	<.001	3	10
LIVER	Positive regulation of supramolecular fiber organization →	+0.094	+2.133	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,878 associations by consensus.

Actin filament organization by SH3BP4 expression — BONE

Explore this box plot interactively →