SH3BP2

Across TCGA patient cohorts, SH3BP2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,546 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH3BP2-associated genes across cancer lineages are PLCD3, LILRA1, and SOD2. Each is linked with SH3BP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3BP2-to-partner and partner-to-SH3BP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH3BP2 versus PLCD3 in OV, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP2→partner) and Y-score (partner→SH3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLCD3 →	+1.058	+0.389	.007	.009	3	4
UCEC	LILRA1 →	+0.426	+0.262	<.001	.003	3	4
GBM	SOD2 →	+0.991	+0.353	.002	<.001	3	4
UCEC	ADGRE2 →	+0.902	+0.482	<.001	.001	3	4
LSCC	MYO1F →	+0.676	+0.249	<.001	<.001	3	4
UCEC	SIRPB2 →	+0.865	+0.500	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,546 associations by consensus.

SH3BP2 vs PLCD3 — OV

Explore this scatter interactively →