SH3BP2

Across TCGA patient cohorts, SH3BP2 mutation is significantly associated with the RNA expression of many other genes, with 2,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP2-associated genes across cancer lineages are RNY3P11, RNU6-355P, and MIR6803. Each is linked with SH3BP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3BP2-to-partner and partner-to-SH3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P11 grouped by SH3BP2-low versus SH3BP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP2→partner) and Y-score (partner→SH3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNY3P11 →	+0.361	+3.325	.002	.003	3	3
HNSC	RNU6-355P →	+0.258	+7.954	<.001	.008	3	2
UCEC	MIR6803 →	+0.097	+3.777	<.001	.007	3	2
UCEC	UHRF1 →	+0.738	+1.885	<.001	.001	3	2
UCEC	POLH-AS1 →	+0.582	+3.201	<.001	<.001	3	2
UCEC	RNVU1-15 →	+0.415	+1.545	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,040 associations by consensus.

RNY3P11 by SH3BP2 expression — COAD

Explore this box plot interactively →