SH3BP2

Across TCGA cell cohorts, SH3BP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,935 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP2-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Positive regulation of intracellular protein transport. Each is linked with SH3BP2 in more than 11 cancer types. Because this analysis shows association rather than direction, both SH3BP2-to-partner and partner-to-SH3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by SH3BP2-low versus SH3BP2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP2→partner) and Y-score (partner→SH3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.113	+1.189	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.127	+1.504	<.001	<.001	3	12
OVARY	Positive regulation of intracellular protein transport →	+0.080	+1.170	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.100	+1.677	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.084	+1.561	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.076	+1.587	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,935 associations by consensus.

Negative regulation of myoblast fusion by SH3BP2 expression — OVARY

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