SH3BP2

Across TCGA cell cohorts, SH3BP2 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP2-associated genes across cancer lineages are IL36A, IQCF5, and VWA3B. Each is linked with SH3BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP2-to-partner and partner-to-SH3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by SH3BP2-low versus SH3BP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP2→partner) and Y-score (partner→SH3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL36A →	+0.687	+3.919	.001	.001	3	2
SOFT_TISSUE	IQCF5 →	+0.080	+5.977	<.001	.001	3	2
BLOOD_Leukemia	VWA3B →	+0.201	+3.392	<.001	.007	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCDC83 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

IL36A by SH3BP2 expression — BLOOD_Leukemia

Explore this box plot interactively →